Learn About STELARA® (ustekinumab) for Ulcerative Colitis | STELARA®

Rapid relief. 
Lasting remission.

Clinical trials included patients who failed or were intolerant to other medications, including a biologic, prior to STELARA®. After only one intravenous (IV) infusion of STELARA®, the majority of patients saw rapid relief from their UC symptoms in just 8 weeks, with nearly 1 in 5 achieving remission. 4 out of 10 patients were in remission at year 1 after responding to the IV induction dose and continuing treatment with STELARA®. Nearly 7 out of 10 patients had no rectal bleeding at all and also had fewer daily bowel movements at ~2 years.*

Individual results may vary. STELARA® is not for everyone. 
Only you and your doctor can decide if STELARA® is right for you.

The legacy of STELARA®


of combined clinical research and 10+ years on the market 
across indications

425,000+ PATIENTS

are estimated to have been treated with STELARA® for Crohn's disease and other indications in the US

100,000+ PATIENTS

are estimated to have been treated with STELARA® for Crohn's disease and ulcerative colitis in the US

This is based on information licensed from IQVIA™: LAAD claims, NPA, DDD for the period 2009-2020 reflecting estimates of real-world activity and based on custom methodologies developed by Janssen. All rights reserved.

Estimations are based on total STELARA® distributed for CD (91,000) and UC (9,000) from October 2016 to July 2020.

What is STELARA® and how does it work?

  • STELARA® is a prescription biologic medicine
  • Many biologics are made from proteins, genes, or antibodies
  • Some biologics target enzymes or proteins that may cause inflammation—like the inflammation thought to cause ulcerative colitis symptoms

STELARA® works differently

There are many different naturally occurring proteins in the body that contribute to inflammation. Two of these proteins, interleukin 12 (IL-12) and interleukin 23 (IL-23), have been implicated as important contributors to the chronic inflammation that is a main feature of ulcerative colitis. STELARA® is the only FDA-approved medication that targets these two proteins.

Learn about dosing with STELARA®

Start with a 
IV infusion

STELARA® treatment starts with a one-time intravenous (IV) infusion through a vein in the arm that provides the amount of medication based on your body weight and is administered by a medical professional in a comfortable setting. It takes at least 1 hour to receive the full dose of medicine.

Keep going with 
maintenance injections

After the one-time IV infusion, you will receive STELARA® as an injection under the skin (subcutaneous injection) every 8 weeks. There are 6 injections during the first year of treatment. Your doctor can administer at his or her office, or your doctor will decide if you or a caregiver may give your injections of STELARA® at home.

STELARA® is intended for use under the guidance and supervision of your doctor. If your doctor decides that you or a caregiver may give your injections of STELARA® at home, you should receive training on the right way to prepare and inject STELARA®.

The STELARA® dosing difference

First 52 weeks of therapy after starter doses







After 1 starter IV infusion, which should take at least one hour.






After 2 injections of 80 mg on day 1, then 1 injection of 80 mg on day 15. Dosing with citrate-free HUMIRA®.



STELARA® is a prescription medicine used to treat adults 18 years and older with moderately to severely active ulcerative colitis.



HUMIRA® is a medicine called a tumor necrosis factor (TNF) blocker. HUMIRA® is used in adults to help get moderate to severe ulcerative colitis under control (induce remission) and keep it under control (sustain remission) when certain other medicines have not worked well enough. It is not known if HUMIRA® is effective in people who stopped responding to or could not tolerate TNF-blocker medicines.


While these factors are important, there are additional considerations for selecting treatment. Please talk to your doctor about treatment options and what might be right for you.

This presentation is not intended to compare the safety and effectiveness of these treatments. Please refer to each product’s full Prescribing Information for recommended dosing and administration.

§Indicated trademark is registered trademark of its respective owner.


Ask your doctor about the benefits and risks of STELARA®. Prescription medications, including STELARA®, have possible risks involved with treatment, so it's important to discuss them with your doctor.

STELARA® is not for everyone; only your doctor can decide if it's right for you. STELARA® is a prescription medicine that affects your immune system. It can increase your chance of having serious side effects including serious infections, cancer, serious allergic reactions, lung inflammation, and a rare condition called posterior reversible encephalopathy syndrome.

These are not all the possible side effects of STELARA®.

Please read the Important Safety Information located at the bottom of the screen and the Medication Guide for STELARA® to learn more about these and other risks for STELARA®. Discuss any questions you have with your doctor.

In clinical studies, the most common side effects were:

  • nasal congestion, sore throat, and runny nose
  • upper respiratory infections
  • fever
  • headache
  • tiredness
  • itching
  • nausea and vomiting
  • redness at the injection site
  • vaginal yeast infections
  • urinary tract infections
  • sinus infection
  • bronchitis
  • diarrhea
  • stomach pain
  • joint pain

These are not all of the possible side effects of STELARA®. Call your doctor for medical advice about side effects.

You should not receive a live vaccine while taking STELARA®. Before receiving STELARA®, tell your doctor if you have recently received or are scheduled to receive an immunization (vaccine). Tell your doctor if anyone in your house needs a vaccine. The viruses used in some types of vaccines can spread to people with a weakened immune system, and can cause serious problems. You should not receive the BCG vaccine during the one year before taking STELARA® or one year after you stop taking STELARA®.

Is STELARA® right for you?
Ask your doctor today.

When it comes to getting control of your UC symptoms, you are your own best advocate. 
The road to remission starts with an open and honest conversation with your doctor.

The importance of a positive doctor-patient relationship

" Your relationship with your doctor, your ability to communicate with one another, is as vital as your treatment plan itself.

STELARA® patient brochure

If you want to learn more about STELARA®, please download our patient brochure.


The majority of patients treated with STELARA® in a clinical study saw relief from their UC symptoms in just 8 weeks


4 out of 10 patients were in remission at year 1 after responding to IV dose and continuing on STELARA®


First UC medication approved to treat inflammation on and below the surface of the intestine

Individual results may vary. STELARA® is not for everyone. Only you and your doctor can decide if STELARA® is right for you.

Once you and your doctor have decided STELARA® is right for you, Janssen CarePath will help you find the resources you may need to get started and stay on track. We will give you information on your insurance coverage, potential out-of-pocket costs, and treatment support, and identify options that may help make your treatment more affordable.

Support Options for Commercially Insured Patients

Janssen CarePath 
Savings Program||

If you have commercial insurance and your insurance coverage for STELARA® is approved

Check your eligibility and enroll at MyJanssenCarePath.com

Janssen Link||

If your commercial insurance coverage is delayed (>5 business days) or denied

||Both the Janssen CarePath Savings Program and the Janssen Link program are unavailable to individuals who use any state or federal government-funded healthcare program to cover a portion of medication costs, such as Medicare, Medicaid, TRICARE, Department of Defense, or Veterans Administration. These programs are for medication only. Terms expire at the end of each program year and may change.

STELARA® (ustekinumab) for Ulcerative Colitis