How Does STELARA® (ustekinumab) Work?

The Science Behind STELARA®

Crohn’s disease is an autoimmune condition. Even though the exact cause of Crohn’s disease is unknown, potential drivers of Crohn’s disease have been linked to a combination of several factors including your immune system, genetics, and the environment.



Your immune system, which normally responds to foreign threats, microorganisms, and intestinal bacteria, is out of balance and mounts inflammatory attacks against your own body. It is believed that substances in the intestines are mistaken for invading substances. The immune system causes temporary inflammation to combat these substances and lessens the response as you regain your health. In Crohn’s disease, the inflammation can persist long after the time when the immune system should have completed its response.


STELARA® Can Fight Your Crohn’s Disease Inflammation

There are many different naturally occurring proteins in the body that contribute to inflammation. Patients with Crohn's disease are found to have elevated levels of two of these proteins, IL-12 and IL-23.

STELARA® is the only FDA-approved medicine that targets IL-12 and IL-23, which are thought to be associated with gastrointestinal inflammation in Crohn's disease.


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